I would like to see where this goes, but personally I think you should take off from just making the characters anime style and apply it to the world as well. It would give your game a better identity and make it harder to dismiss as a minecraft clone.
Darkout, for example, is a Terraria clone, but it is amazing looking and owns its artistic style.
If you're genuinely passionate and inspired then you should go for it.
Bubb9
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