One of the first things you may notice in the title is that the "B" is missing from VTMB, this is not an accident. The Final Nights is an expansion to an otherwise flawless video game built upon the success of the Camarilla Edition series of mods. The "B" has been removed because this expansion can no longer bare the name Bloodlines as it is so far removed from the original game as to warrant the name change. The idea behind this expansion is, and always will be the notion of a completely new experience unlike we've seen so far. With 7 completely brand new clans, 5 new disciplines, extra quests, new NPCs, new game mechanics and new music, the features seem endless. All of this is being built upon the Camarilla Edition series incorporating such things as the blood timer system, pedestrian blood dolls, and the new combat system. Combined we feel the name Bloodlines must be removed from this game, and thus we now simply have "The Final Nights".
I think the claim that the mod is "so different it can't be called Bloodlines" is dubious at best. There aren't any meaningful changes to the game. I found the blood loss system- not unique to this particular mod, I know- to be pointless and in conflict with canon. I truly don't see the point beyond making the game slightly harder. I think it was a poor choice, as it added nothing to the game but aggravation.
I did enjoy the ability to play as a Salubri, although that was the only clan I had an interest in. I thought the addition of the Laibon bloodlines was a weird choice, but that's more of a matter of personal taste. Some of the additional quests were interesting, but- and I come back to this point again- this is NOT a different game from Bloodlines. I wouldn't belabor this point if the makers hadn't made such a point of it. It IS Bloodlines. The major quests, plot, and endings are identical. This is Bloodlines with a little flavoring, but don't be fooled. If you're looking for a completely new experience, this isn't it.
The mod works well- I didn't have any mechanical problems with it- but I wouldn't really recommend it. I found the Clan Quest one more enjoyable, although not because it was a "radically different experience." I just thought it worked better.
Yes, the majority of my problem with this mod was the blood loss system, but I'm not sure if I can accurately convey what a huge waste of my time it was. I found it so offensive that I felt no need to respect it, so I cheated. But hey, if it sounds good to you, by all means try it out.