The demons came and the marines died. Except one. Your are the last defence against these hell-spawned hordes. Prepare for the most intense mutant-laden, blood-splattered action ever! The texture-mapped virtual world is so real, you don't just play DOOM - you live it.
At the year 2145, right after the events of Doom 3, the Moon Station is invaded by hellspawn forces, quickly taking over the base, with all of it soldiers being possesed. The player assume the role of John Logan, one of four supersoldiers trained by the UAC militar division stationed on the Moon, having the power of regeneration and super strength. He was arrested before the events of the game, being stuck on the infirmary due to allegations of hallucinations... sane or insane, he may be one of the few capable of stopping the catastrophe that is about to be unleashed.