Wintermute Engine Development Kit is a set of tools for creating and running graphical point and click adventure games, both in traditional 2D and 2.5D (3D characters on 2D backgrounds). The kit includes the runtime interpreter and GUI editors for managing and creating the game content as well as the documentation, demonstration data and prefabricated templates.

atelier-sento says

10/10 - Agree (1) Disagree

We are in love with Wintermute. It's the perfect tool for our game.
Very simple to use, very precise and intuitive.
Any other software we tried looked confusing in regard.