try using the anomaly EXE in /bin/AnomalyDX11AVX as the reshade EXE, that should fix it. (assuming your using Dx11)
I have reshade 5.1 working (01.07.2022) fine via that method.
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paulfrench07 - - 1 comments @ P.R.O.S.P.E.R.I.T.Y. Reincarnation ReShade [1.5.1]
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