I am running Generals Zero Hour from a disk on Windows 10 64bit. I'm having no problems with it and I don't use any other program to run Generals, but you could try changing the compatibility on the game to Windows 8 or 7. If that doesn't work, try a fresh install again. Make sure the installation is in the correct directory and/or that the launcher is using the correct executable program.
Jdawg021
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