Though both "Portal Remastered" & "Alive & Kicking" take place in the "Portal 2" setting, I imagine there'll be some creative differences with some of the test chamber designs and especially the BTS areas.
Like in this mod, Test Chamber 18 has a bottomless pit in Ratman's Den, showing off some other test chamber exteriors and catwalks in the background. They probably won't have that same setup in "Alive & Kicking".
LazyLexy
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