Load list of your "Always use" mutators everywhere (include campaign ladder), except network play on other servers
With that mod you can play again UT campaign, with any custom weapons/items. Like NaliWeapon3. Or use SmartStockBots on it.
Add monsters, make weapons and ammo volatile or any other change.
Local use:
After each load UT use Mod menu for activate loader. After that you can play any map (include campaign ladder) with your mutator list (except network play on other servers OFC)
Not activate it if wanna play on ACE servers - ACE kick you.
You need reload UT if wanna play on ACE servers if at least once activate loader during this UT run.
For edit mutator list - start practice session with configured mutator list and turned on "Always use" checkbox.