The game plays great; It's like this orgasmic hybrid of ME1 and ME2, with smoother animations and gunplay. The game is VERY cinematic, even during combat. I grinned when I watched Shepard involuntarily yank his head back from into as bullets pepperd the corner I was peeking around.
Voice acting is the best it's ever been. The dialogue between Shepard and Anderson felt incredibly natural, as did Chatter from Wrex, Garrus, Liara, and Mordin, who all made appearances.
Textures are ugly as sin, though I can expect some mods for that, however, the facial animations seem painfully stiff. Minor Gripes however, and I am VERY optimistic for the game.
The multiplayer is also surprisingly deep and fun as hell. Challenging, too. The improved AI really shows. It isn't just some shoehorned multiplayer mode.