I had been planning to post some experiences of the games in my desura library when played with the desura linux beta, to help improve the user experience.
Unfortunately, my testing has been wildly inconsistent and some builds have been pretty nasty.
Anyway, my results don't particularly hold up to any scientific rigour, so are completely useless. That said, I don't wish to give up on getting them.
Based on what I experienced (on good days): java games work, mono (.NET) may work (I've got 2, and it's 50:50), and everything else probably won't. Running a game from desura is likely to break a game that works when installed natively too (e.g. Braid crashes with GLXUnsupportedPrivateRequest).