Frankly, getting straight to the point here, I love it.
IT USES TOO MUCH GODDAMN RAM!
120k to be exact.
I was really hoping for it to stay in Steam RAM area, which generally for me is around 36k, which I can fully understand. But Desura is like a dumptruck full of RAM. Without Desura running, I could be only using 30% of my RAM, but with it running at a blasting 113-120k, it's clogging up a lot of stuff. Would love to see this get fixed, and it's my only rant about Desura. Otherwise, it's great. It's an indie version of Steam, and thats why I love it.
It's that sexy.