Address 0x4800B1 is related to a map function CellClass::Get_Tile_Rect(...) and not anything related to the mod settings.
All missions you mentioned use "TS Temperate" terrain instead of the "YR Desert" (due to technical game limitations, not because I wanted).
Maybe the ".mix" file was corrupted and when the game tries to read data from a specific cell it crash? Can you download it again?
I mean, if you used the client updater for upgrating to 2.5.10 try the full download packages from this website (I don't mind if installer or the manual ZIP file) installing it in a new folder and vice-versa (upgrading from the 2.5.9 or earlier versions).
FS-21
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