I saw the same thing. It looks like Desura is trying to execute something that isn't a script.
Back up ~/.desura/games/defender-story/defender somewhere.
Then modify it to read:
#!/bin/bash
exec java -Xmx150m -jar defender-full-1.03.jar
The Xmx150m increases the JVM heap size; may not be necessary for you, but I wasn't able to run it without doing this.
cyicbov
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