I've encountered a reproducible crash during the climactic boss battle. Using the Flare Gun at any point during the fight will almost certainly cause a total crash. There's no specific error message provided. It's just a full engine hang nearly every time. I recorded a video of one instance here (Spoiler alert!):
This crash also led me to discover another trying issue: There are no autosaves. The only way I could regain my progress there at the very end of the game was to start a completely new game and work my way from the beginning. This was quite the inconvenience, and a particularly bad time to find out such.
Revenant100
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