Two years after Commander Shepard repelled invading Reapers bent on the destruction of organic life, a mysterious new enemy has emerged. On the fringes of known space, something is silently abducting entire human colonies. Now Shepard must work with Cerberus, a ruthless organization devoted to human survival at any cost, to stop the most terrifying threat mankind has ever faced.
You are Terminated!
LOL
use overload twice, activate armor piercing ammo, shoot it a lot, use a heavy weapon if you want, AND BOOM.
SMG on shields, incinerate / sniper armor, then cloak + melee 4fun.