I got a request for an option to invert the y-axis, so I added one and published new builds. Now if you bring up the pause menu (Escape key any time during regular play) you can toggle the option, and it should persist across play sessions.
If there are any other options that would make the game easier for you to play, please let me know! I'm happy with where the game is at content-wise, but I'm always happy to add new options if they make the game more playable.