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After the invasion of Hell on Earth, UAC soldiers succeeded in capturing a live Spider Mastermind. She was then secretly transported to Thanatos, a colonized planet far away from Earth.
Scientists began their experiments on the specimen which they later named Annie. Annie's purpose was to defend the human race agains Hell should there ever be another encounter. With enhanced abilities, more intelligence and greater power, Annie became the humans' ultimate weapon against evil.
But Hell was never meant to contain. Soon after the experiments, Annie broke loose and left a trail of death in her wake. She summoned a portal, allowing a legion of demons to enter the planet and begin the invasion once again.
The UAC headquarters on Earth recieved a distress call by the last of the remaining UAC personnel on Thanatos. The message that the headquarters recieved was disrupted and chaotic, so the marines sent to deal with the situation didn't know exactly what to expect on Thanatos and were quickly overrun by the invaders.
As the only surviving member of Echo Squad, you pushed forward into the labs, hell-bent on shutting down the installation and facing the biggest threat mankind has ever known...
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