The story is set on September 29, 1998, two months and five days after the events in the original Resident Evil. The T-virus has been released in the sewer system and been digested by rats, which then spread the virus to the city's population, which includes animals as well as humans. As the outbreak begins, two figures make their way into Raccoon City: Leon S. Kennedy, a rookie cop on his first day, and Claire Redfield, a college student looking for her brother, Chris, of the S.T.A.R.S. unit. Leon and Claire quickly find themselves fighting for their lives against massive hordes of zombies in the search for a way out of the city. But there is a creature much more powerful than a normal Zombie lurking in the shadows.

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