When Isaac’s mother starts hearing the voice of God demanding a sacrifice be made to prove her faith, Isaac escapes into the basement facing droves of deranged enemies, lost brothers and sisters, his fears, and eventually his mother. The Binding of Isaac is a randomly generated action RPG shooter with heavy Rogue-like elements.
Once again a copy+paste from my Steam recommendation, because I'm lazy:
"A great, addictive and challenging rogue-like. A playthrough isn't really a matter of hours, but it still took me a total of 22 hours to finally beat the first playthrough. The humour is kind of sinister yet funny. The variety of items, enemies and bosses, procedural level generation and different unlockable characters make sure not a single playthrough is the same. Definitely worth the money! (Note: it might take an hour (or two) to really get into the game so give it some time :) )"